GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9902453 | 1 | rs9912741 | chr17:28359511 | EFCAB5 | chr17:28256874-28435469:+ | -0.31 | -4.25 | 5.04E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs7223966 | 1 | rs9912904 | chr17:61763534 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.41 | 2.72E-5 | Body mass index |
| THYM | cis | rs2028299 | 1 | rs9920775 | chr15:90368273 | AP3S2 | chr15:90373832-90456222:- | -0.41 | -4.65 | 1.09E-5 | Type 2 diabetes |
| THYM | cis | rs9921338 | 1 | rs9921338 | chr16:11416839 | C16orf75 | chr16:11343506-11445617:+ | -0.28 | -4.33 | 3.7E-5 | Vein graft stenosis in coronary artery bypass grafting |
| THYM | cis | rs8050907 | 1 | rs9922925 | chr16:4624892 | NMRAL1 | chr16:4511696-4526307:- | -0.48 | -5.52 | 2.96E-7 | Obesity-related traits |
| THYM | cis | rs4888262 | 1 | rs9923145 | chr16:74686166 | RFWD3 | chr16:74655298-74700779:- | -0.21 | -4.54 | 1.68E-5 | Testicular germ cell tumor |
| THYM | cis | rs7223966 | 1 | rs992416 | chr17:61745905 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.41 | 2.72E-5 | Body mass index |
| THYM | cis | rs4888262 | 1 | rs9929496 | chr16:74668473 | RFWD3 | chr16:74655298-74700779:- | -0.23 | -4.89 | 4.07E-6 | Testicular germ cell tumor |
| THYM | cis | rs4888262 | 1 | rs9931225 | chr16:74699293 | RFWD3 | chr16:74655298-74700779:- | -0.23 | -5.05 | 2.14E-6 | Testicular germ cell tumor |
| THYM | cis | rs10935120 | 1 | rs9968172 | chr3:134231251 | ANAPC13 | chr3:134196547-134204865:- | -0.58 | -8.1 | 1.81E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs9968172 | chr3:134231251 | CEP63 | chr3:134204575-134293852:+ | -0.4 | -5.85 | 6.83E-8 | Height |
| THYM | cis | rs9976767 | 1 | rs9976479 | chr21:43836083 | TMPRSS3 | chr21:43791996-43816200:- | 0.49 | 4.63 | 1.15E-5 | Type 1 diabetes |
| THYM | cis | rs9976767 | 1 | rs9976767 | chr21:43836390 | TMPRSS3 | chr21:43791996-43816200:- | -0.49 | -4.62 | 1.18E-5 | Type 1 diabetes |
| THYM | cis | rs1930961 | 1 | rs997872 | chr22:25878614 | CRYBB2 | chr22:25615612-25627836:+ | 1.1 | 7.33 | 7.64E-11 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs1930961 | 1 | rs997873 | chr22:25878282 | CRYBB2 | chr22:25615612-25627836:+ | 1.12 | 7.51 | 3.14E-11 | Bipolar disorder with mood-incongruent psychosis |